Our research pushes the limits of nanoscale engineering through the fabrication and dynamic tuning of materials and structures with unprecedented control reaching the atomic scale. This leads to the emergence of unique properties and phenomena emerge across physical domains—including electrical, optical, mechanical, and ionic—enabling novel control over light–matter interactions, electronic transport, and exciton dynamics. We investigate and harness these phenomena to develop active and multifunctional devices and systems that establish new paradigms for computing, sensing, and transduction, advancing next-generation intelligent physical systems, distributed sensing, artificial intelligence and quantum technologies